• In the search for more specific inhibitors of uptake Iversen

  2024-04-28

  

  In the search for more specific inhibitors of uptake2, Iversen and Salt (1970) speculated that steroids may potentiate the actions of catecholamines on vascular smooth muscle by inhibiting uptake2-mediated catecholamine clearance of the transmitters. They went on to demonstrate that a variety of ste

• During myeloid cell maturation expression of LO mRNA and pro

  2024-04-28

  

  During myeloid cell maturation, expression of 5-LO mRNA and protein is strongly induced (60–130-fold) by calcitriol (1,25(OH)2D3) and transforming growth factor-β (TGFβ) [6,7]. The upregulation of 5-LO mRNA transcription is mainly due to transcript elongation and mRNA maturation [8,9]. Interestingly

• br Co http www apexbt com media diy images wb

  2024-04-28

  

  Conclusions This paper is the first meta-analysis about the association between SRD5A2 V89L polymorphism and hypospadias risk. The results of this meta-analysis have revealed that V89L polymorphism definitely increases the risk of hypospadias, and the C allele is a genetic risk factor for hypospa

• The present study indicates elevated ATX activity

  2024-04-28

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In urb597 synthesis to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared

• br Breast cancer The interactions between LOX and COX enzyme

  2024-04-27

  

  Breast cancer The interactions between 15-LOX and COX enzymes also affect the outcome of breast cancer. Indomethacin, a COX-1 and COX-2 inhibitor, decreased the growth of human breast cancer (BC) cells in nude mice, as well as slowed the rate of lung metastasis formation [41]. The levels of 12-HE

• We showed that activation of the ATM ATR

  2024-04-27

  

  We showed that activation of the ATM/ATR pathway leads to over-replication through suppression of CDK1 activity, consistent with previous findings that suppression of CDK1 activity is involved in the polyploidization of megakaryocyte and trophoblast cells [36], [37], [38], [39]. Suppression of CDK1

• The main function of ATR CHK

  2024-04-27

  

  The main function of ATR/CHK1 signaling is activating matrix metalloproteinase checkpoint arrest for S and G2 phases in mammalian cells. There are three checkpoints in response to DNA damage: G1/S, G2/M, and S-phase. The G2/M checkpoint can prevent cells that incur DNA damage in G2 phase or progres

• The use of FTAI can

  2024-04-27

  

  The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable antioxidant follicle. Pregnancy rates obtained with FTAI may be comparable or better than those obtained af

• Apelin is involved in various

  2024-04-27

  

  Apelin is involved in various physiological functions, including papain inhibitor contraction (Ashley et al., 2005), vasodilatation (Jia et al., 2007), feeding control (Valle et al., 2008), and metabolic homeostasis (Higuchi et al., 2007, Dray et al., 2008, Attane et al., 2010). Its plasma level is

• Differentiation of skeletal myoblasts is a tightly orchestra

  2024-04-27

  

  Differentiation of skeletal myoblasts is a tightly orchestrated process that involves myoblast proliferation, TAK-632 withdrawal, expression of muscle-specific genes, and fusion into multinucleated myofibers (Horsley and Pavlath, 2004; Krauss, 2010). The maintenance of muscle mass is important for s

• Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases A

  2024-04-27

  

  Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in

• br Results br Discussion Tapinarof GSK

  2024-04-27

  

  Results Discussion Tapinarof (GSK2894512) is a naturally derived investigational topical medicine with demonstrated clinical efficacy for patients with AD and psoriasis (Bissonnette et al., 2010, Bissonnette et al., 2012a). The drug substance is a polyphenol produced by bacteria that is struct

• The rank order of agonist

  2024-04-27

  

  The rank order of agonist potency in turkey cardiac chambers demonstrated the predominant presence of the β-adrenergic receptor subtype, in line with the receptor classification by . However, a previous radioligand binding study in the left ventricles of 7-week old turkeys reported the existence of

• br Introduction Nausea and vomiting are among

  2024-04-27

  

  Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

• Epithelial mesenchymal transition EMT is the process

  2024-04-26

  

  Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical graphpad molarity cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and repr

16070 records 151/1072 page Previous Next First page 上5页 151152153154155 下5页 Last page