• br Structures of human secretase Before the near

  2021-12-03

  

  Structures of human γ-secretase Before the near-atomic resolution structures, the highest resolutions achieved for γ-secretase were 15 and 12Å [19, 21]. The 15-Å structure revealed a Amikacin chamber in the transmembrane domain and two pores at the top and bottom of γ-secretase, which were specu

• Many investigators have noted structural similarities betwee

  2021-12-03

  

  Many investigators have noted structural similarities between certain flavonoids and benzodiazepines, such as diazepam, that are the most widely studied positive modulators of GABAA receptors. Benzodiazepines can act on these receptors via ‘two distinct and separable mechanisms’ (Walters, Hadley, Mo

• With the nitrogen containing heterocycle components

  2021-12-03

  

  With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic ASP015K (, and ), followed by deprotection by TFA, smoothly provided the c

• C prevents the glutamate and erastin induced

  2021-12-03

  

  C16 prevents the glutamate- and erastin-induced ROS accumulation but does not affect the decrease in GSH, indicating that prevention of ROS accumulation by C16 is not due to the restoration of GSH levels. Instead, C16 itself possessed superoxide anion scavenging activity in vitro at similar concentr

• Although epigenetic mechanisms are implicated in the pathoge

  2021-12-03

  

  Although epigenetic mechanisms are implicated in the pathogenesis of hematopoietic malignancies, little is known about the role of lysine-specific histone demethylases and whether manipulation of these enzymes can be translated into targeted therapies. KDM6A is the most frequently mutated histone de

• br Conflict of interest br Funding This work

  2021-12-03

  

  Conflict of interest Funding This work was supported by the National Institutes of Health MSK Cancer Center Support Grant/Core Grant [P30 CA008748]. The funding source had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report;

• Interestingly the virulence of HBV may

  2021-12-03

  

  Interestingly, the virulence of HBV may adaptively evolve, thus affecting the macroscopic propagation of hepatitis B. Higher virulence in vivo may result in a higher transmission rate and mortality. By assuming that the transmission rate is a monotonically increasing function of virulence, , we pro

• HBV VL quantitation has been shown to be affected

  2021-12-03

  

  HBV VL quantitation has been shown to be affected by genotype/subtype, and varying degrees of positive and negative bias has been seen in previous comparison studies when analyzing across HBV genotypes. In studies comparing RealTime and Cobas for example, negative bias of ∼0.25 log10 was seen for ge

• Studies utilising GPR mice however report different

  2021-12-03

  

  Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice

• monooxygenase By contrast pentameric glycine receptors

  2021-12-02

  

  By contrast, pentameric glycine receptors (GlyR) in humans have four functional subunits, α1− α3 and β (Lynch, 2004) whereas the retina of other mammals have an additional α4 subunit (Harvey et al., 2000), and in humans the α4 subunit is considered a pseudogene as it lacks the 4th transmembrane doma

• br Electron crystallographic structures of connexins The

  2021-12-02

  

  Electron crystallographic structures of connexins The structures of gap junctions are good targets for electron microscopy because they exhibit the characteristic features of self-assembly. Early studies examined the three-dimensional (3D) structures of native gap junction Lamivudine receptor fr

• These reports have gradually established

  2021-12-02

  

  These reports have gradually established G-quadruplex binding small molecules as promising anti-cancer therapeutic agents. Besides the stabilization of G-quadruplex structures, some of these molecules also serve as diagnostic probes and sensors for G-quadruplexes in vitro and in vivo. Of these, Thio

• This connection is supported by studies in

  2021-12-02

  

  This connection is supported by studies in the SIV macaque model of HIV, where treatment with methamphetamine, which greatly enhances CNS dopamine levels (Truong, 2005); increased PD123319 viral load. Methamphetamine also increased expression of the HIV co-receptor CCR5 in CNS macrophages, thereby

• br Conflicts of interest br Significance p is required

  2021-12-02

  

  Conflicts of interest Significance p53 is required for the induction of cell senescence to limit the proliferation of polyploid cells. We found that Hippo signal deficiency or Yap activation in mouse livers result in polyploid formation and polyploid cell growth. The combined loss of Hippo sig

• br Reactive Dicarbonyls and Mitochondrial

  2021-12-02

  

  Reactive Dicarbonyls and Mitochondrial Dysfunction Although mitochondrial dysfunction has been suggested to be one of the main pathogenic mechanisms in diabetic neuropathy, little is known about the nature and extent of mitochondrial damage resulting from chronic hyperglycemia. Mitochondria funct

15791 records 531/1053 page Previous Next First page 上5页 531532533534535 下5页 Last page