• br Conclusions Temporally controlled disruption of Gcgr reve

  2021-11-01

  

  Conclusions Temporally-controlled disruption of Gcgr reveals a lack meaningful contribution to the improvement of glycemic control in insulinopenic conditions attributable to the intrinsic loss of GCGR signaling. On the other hand, these data highlight the importance of compensatory systems, incl

• The most classic case of

  2021-11-01

  

  The most classic case of acquired and relapsing epilepsy is temporal lobe epilepsy (TLE), which originates from the hippocampal formation, a structure situated in the mesial temporal lobe (Majores et al., 2007). Our experiment used the prominent pilocarpine-induced TLE model. Systemic administration

• The central event eliciting insulin secretion is the product

  2021-11-01

  

  The central event eliciting insulin secretion is the production of ATP which leads to the inhibition of ATP-sensitive inwardly-rectifying K+ATP channels, a consecutive depolarization of the plasma membrane with opening of voltage-dependent Ca2+ channels and Ca2+ influx into the beta-cell. However, i

• Surface enhanced Raman spectroscopy SERS is one

  2021-11-01

  

  Surface-enhanced Raman spectroscopy (SERS) is one of the most powerful and ultra-sensitive analytical tools, which has been widely applied to food security analysis and many other fields (Craig, Franca, & Irudayaraj, 2013; Gukowsky, Xie, Gao, Qu, & He, 2018; Qi et al., 2013; Zhang et al., 2015). For

• Tyrphostin 9 receptor Having identified initial leads and fu

  2021-10-29

  

  Having identified initial leads and (), further lead optimization was initiated on B- and C-rings to afford compounds with improved potency. Initial set of substituted imidazole-biphenyl-carboxylic Tyrphostin 9 receptor derivatives – and () were evaluated for GSNOR potency. Among this, fluoro, m

• Similar to GPR A activation of G protein coupled

  2021-10-29

  

  Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic SP2509 synthesis receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1974, Cai et al., 2008, Gold et al., 196

• This data is in accordance with our recent results on

  2021-10-29

  

  This data is in accordance with our recent results on the influence of cholesterol-depleting agent methyl-β-cyclodextrin on platelets (Borisova et al., 2011a). Dissipation of the proton electrochemical gradient of secretory granules by methyl-β-cyclodextrin did not evoke the release of endogenous gl

• br Conclusions The results of this work

  2021-10-29

  

  Conclusions The results of this work showed that β-glucosidase could be efficiently immobilized onto hydroxyapatite nanoparticles in a single adsorption step. The enzyme adsorption was accomplished by coordination bonds between remaining Ca2+ sites of HA and COO− of amino acids. The immobilizatio

• br Glucocorticosteroid receptor structure and

  2021-10-29

  

  Glucocorticosteroid receptor structure and function The gene encoding for the human GR is composed of 9 exons (Oakley and Cidlowski, 2011) and the translated protein is described as having 4 functional regions. The protein contains a highly conserved central DNA-binding domain (DBD) or C-domain,

• br Experimental br Results br Discussion The use of

  2021-10-29

  

  Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,

• Since our new compound Fex

  2021-10-29

  

  Since our new compound Fex-3 could be a new FXR ligand, we try to demonstrate that Fex-3 was an intestinal-restricted FXR agonist which only activated FXR in the intestine not in the liver or other organs. Initially, we investigated this in Caco-2 Edoxaban receptor with transwell experiments. From

• Sensitivity to EphB TKI was also

  2021-10-29

  

  Sensitivity to EphB3 TKI was also demonstrated in a colon cancer cell line, COLO 205, with high expression of EphB3. We found not only exogenous but also endogenous EphB3 protein was expressed in the COLO 205 Ivacaftor benzenesulfonate after transient transfection of pCMV6-AC-GFP/EphB3, and both wer

• Sephin 1 Genetic contributions to this dysregulation of expr

  2021-10-29

  

  Genetic contributions to this dysregulation of expression have been studied, and significant associations have been found. The Fas −670 polymorphism is associated with preterm premature rupture of membranes, preeclampsia, as well as intrauterine growth restriction [7], [16]. The Fas SNP (−670 A>G) i

• Trifluoromethyl ketones and fluorophosphates were the first

  2021-10-29

  

  Trifluoromethyl ketones and fluorophosphates were the first generation FAAH inhibitors identified. They showed good in vitro FAAH inhibition potency, but most of them exhibited poor selectivity for FAAH over other serine hydrolases (such as the triacylglycerol hydrolase and the membrane-associated h

• Tyr phosphorylation of AnxA was

  2021-10-29

  

  Tyr23 phosphorylation of AnxA2 was first reported to be involved in endocytosis, particularly in the internalisation of the insulin receptor [20]. Phosphorylated Tyr23 seems to be necessary for the stable association of AnxA2 with endosomes, and for their early-stage transport [14]. The role of AnxA

16096 records 572/1074 page Previous Next First page 上5页 571572573574575 下5页 Last page