• br Introduction Diacylglycerol kinase DGK is

  2020-02-03

  

  Introduction Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic Mouse iPSC Chemical Reprogramming Cocktails Kit plus (PA) [[1], [2], [3], [4]]. DG and PA act as lipid second messengers in a wide variety of biological process

• DDI is one of the

  2020-02-03

  

  DDI is one of the main problems with serious clinical consequences in clinical settings. Several reports have highlighted the role of modulation of drug-metabolizing enzymes, especially CYP450 s, as a major mechanism involved in clinical DDIs [3,4,7]. The present study aimed to investigate the effec

• Several mechanisms are implicated in lipid induced

  2020-02-03

  

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012). Mitochondrion is a major source of ROS production. The oxidation of pyruvate and fatty cgrp antagonist yielding acetyl-CoA oc

• To determine the time course of ZD

  2020-02-03

  

  To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour Nitidine chloride were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggesting

• It is well known that the tumor suppressor

  2020-02-03

  

  It is well known that the tumor suppressor p53 plays an important role in regulating the Lamivudine and cellular senescence [43,46,48]. For example, FOXO4 could interact with P53, which selectively induced apoptosis in senescent cells [48]. In addition, loss of MECP2 was found to lead to the inducti

• Assessment of DNA damage by comet assay and

  2020-02-03

  

  Assessment of DNA damage by comet assay and ChEs activity has been widely used as a biomarker of genotoxicity and exposure to pesticide respectively, to measure the risk related to pesticides in the exposed population [15]. Very few studies have explored the association between DNA damage and worke

• NPC L expression is both tissue and species

  2020-02-03

  

  NPC1L1 expression is both tissue- and species-specific. Consistent with its function, NPC1L1 is mainly localized to the brush border membrane of enterocytes and the canalicular membrane of hepatocytes. NPC1L1, which is expressed in the liver of humans and rats but not mice, mediates cholesterol XAV-

• br Methods br Results Main characteristics of study

  2020-02-03

  

  Methods Results Main characteristics of study population are presented in Table 1. AD cases had higher co-morbidity score and lower socioeconomic position than controls. Women with AD had undergone any surgery (unilateral/bilateral oophorectomy, hysterectomy, hysterectomy with bilateral oophor

• Prostaglandin E PGE is involved

  2020-02-03

  

  Prostaglandin E2 (PGE2) is involved in several biological processes such as renal function, inflammation, angiogenesis, and tumor growth. The various biological effects of PGE2 are mediated by the so-called E-type prostanoid receptors (EP1 to EP4). Among these, the EP4 receptor has been well studied

• br Materials and Methods br Results

  2020-02-03

  

  Materials and Methods Results Discussion Viral infection of eukaryotic 1568 activate signaling pathways both via specific interaction with pattern recognition receptors (TLRs, RIG-I, MDA5) and more nonspecific mechanisms such as accumulation of newly synthesized viral glycoproteins in the E

• Results of the present study demonstrate

  2020-02-03

  

  Results of the present study demonstrate that 25-OHC treatment of THP-1 monocytes induced vimentin intermediate filament reorganization to more cortical structures and a polarized phenotype (Fig. 5). Vimentin is the major intermediate filament protein present in leukocytes and plays an important rol

• br Contributors br Acknowledgements br

  2020-02-03

  

  Contributors Acknowledgements Introduction Pemphigus disorders are characterized by autoantibodies binding to desmosomes between epidermal cells, resulting in the loss of cell to cell adhesion and blister formation. In pemphigus foliaceus, autoantibodies predominantly bind to desmoglein 1,

• In the particular case of

  2020-01-30

  

  In the particular case of metals, several authors showed that AChE inhibition is somewhat contradictory and even questionable (Frasco et al., 2005, Nunes et al., 2005, Sáenz et al., 2010). Uranium is a particular metal, and one that has been shown to complex with several biologically important prote

• Not all of the biological activities exhibited

  2020-01-30

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the DMH-1 receptor is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to resp

• While PRRSV has been recently shown to induce SGs

  2020-01-29

  

  While PRRSV has been recently shown to induce SGs, the exact nature of SG formation and its underlying mechanism of regulating antiviral immune response during PRRSV infection remain unclear (Zhou et al., 2017). Formation of PRRSV-induced SGs was observed in MARC145 csf1r (Chen et al., 2018) and PA

16070 records 914/1072 page Previous Next First page 上5页 911912913914915 下5页 Last page